徐小文 讲师

研究方向：鱼类应激反应与免疫应答

任职：水生水产研究所

邮箱：xuxw2020@163.com

教育经历：

2016/09—2019/07 16877太阳集团安全入口，16877太阳集团安全入口，博士研究生/博士

工作经历：

1: 2022/08—至今 16877太阳集团安全入口，16877太阳集团安全入口，讲师

2: 2019/07—2022/06 16877太阳集团安全入口，16877太阳集团安全入口，博士后

执教课程：

本科生课程：《动物生理学》

研究生课程：《细胞生物学技术》、《高级细胞生物学技术》

主持课题项目：

1. 国家自然科学基金地区项目，以Z-DNA为免疫原的鱼用核酸疫苗制备的理论基础(32160872)，2022.01-2025.12，在研。

2. 江中制药集团横向项目，中药材发酵产物对胃癌细胞及结肠癌细胞增殖影响的研究(HX202111150001)，2021.09-2022.09，结题。

3. 16877太阳集团安全入口第三届学科交叉创新基金，基于偏振调制稀疏重建的超分辨荧光成像技术(28220007-YB2111)，2021.01-2023.12，在研。

4. 中国博士后科学基金面上项目，基于Z-DNA的鱼用DNA疫苗的研发(2019M662279)，2020.01-2022.06，结题。

5. 江西省博士后基金择优资助，基于Z-DNA的鱼用新型DNA疫苗的研发(2019KY43)，2020.01-2022.06，结题。

代表性论文：

[1] Han X^#, Xu X#, Yu T, Li M, Liu Y, Lai J, Mao H, Hu C, Wang S. Diflubenzuron Induces Cardiotoxicity in Zebrafish Embryos. International Journal of Molecular Sciences, 2022, 23, 11932. (Co-First author)

[2] Xiong Y, Wang C*, Dong M, Li M, Hu C, Xu X*. Chlorphoxim induces neurotoxicity in zebrafish embryo through activation of oxidative stress. Environmental Toxicology, 2022, 10: 1-13. (Corresponding author)

[3] Yu T^#, Zeng Q^#, Mao H*, Liu Y, Zhang H, Wang S, Hu C, Xu X*. Grass carp (Ctenopharyngodon idella) NLK2 inhibits IFN I response through blocking MAVS-IRF3 axis. Fish and Shellfish Immunology, 2022, 131: 206-217. (Corresponding author)

[4] Wang S^#, Han X, Yu T, Liu Y, Zhang H, Mao H, Hu C,Xu X*. Isoprocarb causes neurotoxicity of zebrafish embryos through oxidative stress-induced apoptosis. Ecotoxicology and Environmental Safety, 2022, 242, 113870. (Corresponding author)

[5] Li M^#, Hu J, Mao H, Li D, Jiang Z, Sun Z, Yu T, Hu C*, Xu X*. Grass Carp (Ctenopharyngodon idella) KAT8 inhibits IFN 1 response through acetylating IRF3/IRF7. Frontiers in Immunology, 2022, 12, 808159. (Corresponding author)

[6] Xu X#, Li M, Deng Z, Li D, Lu S, Deng H, Lv Y, Liu Y, Du H, Hu C*. Grass carp Mre11A activates IFN 1 response by targeting STING to defend against GCRV infection. Developmental andComparativeImmunology, 2021, 116, 103909. (First author)

[7] Xu X#, Li M, Deng Z, Hu J, Jiang Z, Liu Y, Chang K, Hu C*. Grass carp (Ctenopharyngodon idellus) NIMA-related kinase 6 (NEK6) blocks dsRNA-induced IFN I response by targeting IRF3. Frontiers inImmunology, 2021, 11, 597775. (First author)

[8] Xu X#, Li M, Deng Z, Li D, Wang S, Hu C*. cGASa and cGASb from grass carp (Ctenopharyngodon idellus) play opposite roles in mediating type I interferon response. Developmental andComparativeImmunology, 2021, 125, 104233. (First author)

[9] Lu S^#, Peng X, Lin G, Xu K, Wang S, Qiu W, Du H, Chang K, Lv Y, Deng H, Hu C, Xu X*. Grass carp (Ctenopharyngodon idellus) SHP2 suppresses IFN I expression via decreasing the phosphorylation of GSK3β in a non-contact manner. Fish and Shellfish Immunology, 2021, 116, 150-160. (Corresponding author)

[10] Li M^#, Yu T, Lai J, Han X, Hu J, Deng Z, Li D, Ye Z, Wang S, Hu C*, Xu X*. Ethoprophos induces cardiac toxicity in zebrafish embryos. Ecotoxicology and Environmental Safety, 2021, 228, 113029. (Corresponding author)

[11] Xu X#, Li M, Wu C, Jiang Z, Liu C, Cheng B, Li D, Mao H, Hu C*. The fish-specific protein kinase (PKZ) initiates innate immune responses via IRF3- and ISGF3-like mediated pathways. Frontiers inImmunology, 2019,10, 582. (First author)

[12] Xu X#, Li M, Li D, Jiang Z, Liu C, Shi X, Wu C, Chen X, Lin G, Hu C*. Identification of the SAMHD1 gene in grass carp and its roles in inducing apoptosis and inhibiting GCRV proliferation. Fish and Shellfish Immunology, 2019, 88: 606-618. (First author)

[13] Xu X#, Li M, Wu Z, Wang H, Wang L, Huang K, Liu X, Hou Q, Lin G, Hu C*. Endoplasmic reticulum transmembrane proteins ZDHHC1 and STING both act as direct adaptors for IRF3 activation in teleost. Journal of Immunology, 2017, 199: 3623-3633. (First author)

[14] Xu X#, Lai Q, Gua M, Liu D, Hou Q, Liu X, Mi Y, Sun Z, Wang H, Lin G, Hu C*. Fish IRF3 up-regulates the transcriptional level of IRF1, IRF2, IRF3 and IRF7 in CIK cells. Fish and Shellfish Immunology, 2015, 47: 978-985. (First author)