罗韬

16877太阳集团(中国)安全入口-Best Green App

罗韬 研究员硕士生导师

研究方向:生殖生物学

主要荣誉及专业团队任职:江西省“双千”首批科技创新高端人才(青年类)16877太阳集团安全入口“香樟俊才”和“赣江青年学者”获江西省自然科学三等奖和第19届鲁瓦扬国际研究奖提名;现为16877太阳集团安全入口生命科学研究院离子通道与疾病实验室负责人16877太阳集团安全入口临床医学实验中心开放性大学生创新实验室兼职主任;任国家科技专家库在库专家、国家自然科学基金委同行评议专家、中国药理学会生殖药理专业委员会委员、妇幼健康研究会安全避孕专业委员会第一届委员、中华医学会计划生育分会第一届交叉前沿学组委员等职

邮箱:luotao@ncu.edu.cn

主持课题项目:

1国家自然科学基金面上项目:人精子运动相关的赖氨酸琥珀酰化修饰调控网络及其在弱精子症中的作用【批准号:82071708;起止时间:2021-2024

2中央引导地方科技发展专项资金-国家自然科学基金优青培育项目赖氨酸酰化新修饰2-羟基异丁酰化调控人精子运动的作用机制【批准号:20202ZDB01013;起止时间:2020-2021

3、国家自然科学基金面上项目:PAQR7在精子响应孕酮能力下降的男性不育症中的作用机制【批准号:81771644;起止时间:2018-2021

4科技部国家重点研发专项避孕节育及兼有治疗作用的新药具研发子任务【批准号:2016YFC1000905;起止时间:2016-2021

5、国家自然科学基金青年项目:弱精症相关hPAQR7受体在人成熟精子孕酮信号转导中的作用机制【批准号:31400996;起止时间:2015-2017

6江西省“双千”计划-首批科技创新高端人才(青年)项目【批准号:jxsq2019201091;起止时间:2020-2023

7、江西省自然科学基金青年重点项目CatSper相互作用膜蛋白与人精子功能调控【批准号:20171ACB21006;起止时间:2017-2019

代表性论文:

1. Successful outcomes of intracytoplasmic sperm injection–embryo transfer using ejaculated spermatozoa from two Chinese asthenoteratozoospermic brothers with a compound heterozygous FSIP2 mutation. Andrologia, 2021, 00:e14351(通讯作者)

2. N-Methyl-D-aspartic Acid (NMDA) Receptor Is Involved in the Inhibitory Effect of Ketamine on Human Sperm Functions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22(22): 12370(通讯作者)

3. Testis developmental related gene 1 (TDRG1) encodes a progressive motility-associated protein in human spermatozoa. Human Reproduction, 2021, 36(2): 283–292.(通讯作者)

4. What is the Impact of Bisphenol A on Sperm Function and Related Signaling Pathways: A Mini-review? Curr Pharm Design, 2020, 26(37): 1-7.(通讯作者)

5. Posttranslational lysine 2-hydroxyisobutyrylation of human sperm tail proteins affects motility. Human Reproduction, 2020, 35(3): 494-503.(通讯作者)

6. Effects of the environmental endocrine disruptors di-2-ethylhexyl phthalate and mono-2-ethylhexyl phthalate on human sperm function in vitro. Reprod Fertil Dev, 2020, 32(6): 629-636. (通讯作者)

7. In vitro exposure to metformin activates human spermatozoa at therapeutically relevant concentrations. Andrology, 2020, 8: 663–670.(通讯作者)

8. Anethole compromises human sperm function by affecting the sperm intracellular calcium concentration and tyrosine phosphorylation. Reprod Toxicol, 2020, 93, 99-105(通讯作者)

9. Diet-induced obesity is associated with altered expression of sperm motility-related genes and testicular post-translational modifications in a mouse model. Theriogenology, 2020, 158: 233-238.通讯作者

10. Lysine glutarylation in human sperm is associated with progressive motility. Human Reproduction, 2019, 34(7), 1186-1194.通讯作者

11. A novel copy number variation in CATSPER2 causes idiopathic male infertility with normal semen parameters. Human Reproduction, 2019, 34(3), 414-423(第一作者)

12. Rosmarinic acid compromises human sperm functions by an intracellular Ca2+ concentration-related mechanism. Reprod Toxicol, 2018, 81, 58-63.(通讯作者)

13. Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa. Human Reproduction, 2017, 32(2), 290-298. (通讯作者)

14. Lead Inhibits Human Sperm Functions by Reducing the Levels of Intracellular Calcium, cAMP, and Tyrosine Phosphorylation. Tohoku J Exp Med, 2016, 238, 295-303. (通讯作者)

15. Ketamine inhibits human sperm function by Ca2+-related mechanism. Biochem Biophys Res Commun, 2016, 478, 501-506. (通讯作者)

16. Matrine compromises mouse sperm functions by a [Ca2+]i-related mechanism. Reprod Toxicol, 2016, 60, 69-75. (通讯作者)

17. Emodin inhibits human sperm functions by reducing sperm [Ca2+]i and tyrosine phosphorylation. Reprod Toxicol, 2015, 51, 14-21. (第一作者)

获批专利:

1. 专利名称:用于制备mPRa单克隆抗体的免疫原。专利号:ZL201910552308.X(第一发明人),授权公告日:2021824日,授权公告号:CN 110372786 B.

2. 专利名称:一种黄酮类化合物及其制备方法和应用。专利号:ZL202010250678.0(第二发明人),授权公告日:2021518日,授权公告号:CN 111675719 B.

3. 专利名称:一种精子活力检测装置。专利号:ZL202121005969.X(第二发明人),授权公告日:20211210日,授权公告号:CN 215115920 U.

4. 专利名称:用于制备LRRC52多克隆抗体的免疫原。专利号:ZL201410295554.9(第三发明人),授权公告日:2016119日,授权公告号:CN 104211798 B.